The signs of blood clots are:. Stroke can cause serious medical problems, including death. The signs of stroke are:. Cataracts or increased chance of needing cataract surgery. The sign of these problems is slow blurring of your vision. Liver problems, including jaundice. The signs of liver problems include lack of appetite and yellowing of your skin or whites of your eyes. Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.
Especially tell your doctor if you take:. This is not a complete list of tamoxifen drug interactions. Medicines can interact with certain foods.
In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of tamoxifen there are no specific foods that you must exclude from your diet when receiving tamoxifen.
Tell your doctor about all the prescription medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Tell your doctor if you are pregnant or plan to become pregnant while taking tamoxifen or during the 2 months after you stop taking tamoxifen.
Tamoxifen may harm your unborn baby. It takes about 2 months to clear tamoxifen from your body. To be sure you are not pregnant, you can start taking tamoxifen while you are having your menstrual period. Or, you can take a pregnancy test to be sure you are not pregnant before you begin.
Tell your doctor if you are breastfeeding or plan to breastfeed. It is not known if tamoxifen is excreted in human breast milk or if it will harm your nursing baby. Take tamoxifen exactly as prescribed by your doctor. Follow the directions on your prescription label carefully. Your doctor will determine the best dose for you. For patients with breast cancer, the recommended daily dose is mg. Dosages greater than 20 mg per day should be given in divided doses morning and evening.
There are no data to support the use of tamoxifen other than for 5 years. If you take too much tamoxifen, call your local Poison Control Center or seek emergency medical attention right away. Uterine malignancies consist of both endometrial adenocarcinoma incidence rate per 1, women-years of 2. For stroke, the incidence rate per 1, women-years was 1. For pulmonary embolism, the incidence rate per 1, women-years was 0. Health care providers should discuss the potential benefits versus the potential risks of these serious events with women at high risk of breast cancer and women with DCIS considering tamoxifen to reduce their risk of developing breast cancer.
The benefits of tamoxifen outweigh its risks in women already diagnosed with breast cancer. Tamoxifen treats and prevents breast cancer. It is taken typically for 5 years, unless your doctor tells you otherwise.
A common side effect is hot flashes. This is not a serious problem. Tamoxifen Overview Updated: March 28, This medication comes in a tablet and an oral solution and is usually taken once or twice a day. Tamoxifen Genetic Information.
How was your experience with Tamoxifen? First, a little about yourself Male Female. What tips would you provide a friend before taking Tamoxifen? Choose one. Back Next. How well did Tamoxifen work for you? Did you experience many side effects while taking this drug?
Tamoxifen may cause hot flashes and increase the risk of blood clots and stroke. Aromatase inhibitors may cause muscle and joint aches and pains.
Less common but more severe side effects of aromatase inhibitors are heart problems, osteoporosis, and broken bones. Endometrial cancer is a less common but more severe side effect of tamoxifen. Because so many women stop taking tamoxifen early, researchers wondered if a lower dose of tamoxifen could still reduce the risk of invasive breast cancer and cause fewer or less severe side effects. Half the women were followed for longer than 5 years, and half the women were followed for shorter periods of time.
The results showed that the low dose of tamoxifen helped reduce the risk of invasive breast cancer. During follow-up:. Ospediali Galliera — S. Oncologia Medica in Genoa, Italy. The most important implication is among the women who are healthy but who may be at risk for breast cancer, [that they] may benefit from a lower dose of tamoxifen. De Censi said that if compliance to treatment had been higher, he would have expected to see a greater benefit of tamoxifen.
He also mentioned that tamoxifen currently is only available in mg tablets, but prior studies have shown that 10 mg every other day is as effective as 5 mg per day at reducing the risk of invasive disease.
Overall, women taking the low dose of tamoxifen had only slightly more side effects than the women taking placebo:. The smallest tablets we have are 10 mg, so to split them more than in half would be difficult. I think that for the time being, 5 mg would seem to be a good dose. How should this medicine be used? Other uses for this medicine What special precautions should I follow? What should I do if I forget a dose? What side effects can this medication cause? What should I know about storage and disposal of this medication?
Brand names. Other uses for this medicine. What special precautions should I follow? Before taking tamoxifen, tell your doctor and pharmacist if you are allergic to tamoxifen or any other medications. Be sure to mention any of the following: aminoglutethimide Cytadren ; anastrozole Arimidex , bromocriptine Parlodel ; cancer chemotherapy medication such as cyclophosphamide Cytoxan, Neosar letrozole Femara ; medroxyprogesterone Depo-Provera, Provera, in Prempro ; phenobarbital; and rifampin Rifadin, Rimactane.
Your doctor may need to change the doses of your medications or monitor you carefully for side effects. You should not plan to become pregnant while taking tamoxifen or for 2 months after your treatment. Your doctor may perform a pregnancy test or tell you to begin your treatment during your menstrual period to be sure that you are not pregnant when you begin taking tamoxifen.
You will need to use a reliable nonhormonal method of birth control to prevent pregnancy while you are taking tamoxifen and for 2 months after your treatment. Talk to your doctor about the types of birth control that are right for you, and continue to use birth control even if you do not have regular menstrual periods during your treatment. Stop taking tamoxifen and call your doctor right away if you think you have become pregnant during your treatment. Tamoxifen may harm the fetus.
You should not breastfeed during your treatment with tamoxifen. Talk to your doctor about how often you should examine your breasts yourself, have a doctor examine your breasts, and have mammograms x-ray examinations of the breasts. Call your doctor right away if you find a new lump in your breast. Tamoxifen may cause side effects.
Tell your doctor if any of these symptoms are severe or do not go away: increased bone or tumor pain pain or reddening around the tumor site hot flashes nausea excessive tiredness dizziness depression headache thinning of hair weight loss stomach cramps constipation loss of sexual desire or ability in men Some side effects can be serious.
If you experience any of the following symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately: vision problems loss of appetite yellowing of the skin or eyes unusual bruising or bleeding fever blisters rash swelling of the eyes, face, lips, tongue, throat, hands, arms, feet, ankles, or lower legs thirst muscle weakness restlessness Tamoxifen may increase the risk that you will develop other cancers, including liver cancer.
Symptoms of overdose may include: uncontrollable shaking of a part of the body unsteadiness dizziness. What other information should I know? Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to tamoxifen. Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking tamoxifen. Do not let anyone else take your medication.
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